We propose the term "atypical sarcoid-like granuloma" for this form of hepatic granuloma in the cat. Instead, it consisted of well-demarcated, noncaseating granulomas containing well-formed epithelioid and lymphocytic cell cuffing. The granuloma was, however, atypical for sarcoid granuloma, as it did not stain positive for acid-fast bacteria and it lacked an eosinophilic core. In addition, the granulomas contained occasional epithelioid and plasmacytoid cells, consistent with a diagnosis of sarcoid-like granuloma. Some of the granulomas contained large numbers of multinucleated giant cells, and the central caseating granulomas contained numerous acid-fast bacteria. This was composed of a central caseating granuloma surrounded by a palisaded epithelioid and lymphocytic cell cuff. Microscopic examination of a liver biopsy sample revealed a well-demarcated, well-formed lobular granuloma within the hepatic parenchyma. Serum biochemical analysis revealed increased alanine aminotransferase (ALT) and cholesterol and decreased alkaline phosphatase (AP) and triglycerides. Hepatomegaly and icterus were evident on physical examination. DRM-FREEAtypical sarcoid-like granulomas, consisting of noncaseating granulomas with epithelioid cells, in the liver of a cat.Ī 13-year-old castrated male domestic shorthair cat was presented for evaluation of anorexia and lethargy.
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